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Leaf Spray Mass Spectrometry: A Rapid Ambient Ionization Technique to Directly Assess Metabolites from Plant Tissues

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Sceletium--a review update.

N Gericke¹, A M Viljoen

¹P.O. Box 937, Sun Valley 7985, South Africa.

Journal of Ethnopharmacology

|September 2, 2008

Summary

This summary is machine-generated.

Sceletium, a plant used for millennia by indigenous peoples, shows potential for dietary supplements and phytomedicine. New research validates traditional uses and explores its alkaloid chemistry for novel drug applications.

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Area of Science:

Ethnobotany and Phytochemistry
Pharmacology

Background:

Plants of the genus Sceletium have been utilized for millennia by indigenous South African peoples, including San hunter-gatherers and Khoi pastoralists.
Traditional uses encompassed mastication, relief from thirst and hunger, fatigue combat, medicinal purposes, and social/spiritual practices.

Observation:

Indigenous knowledge of Sceletium has diminished due to historical conflicts, land loss, disease, and acculturation.
Wild Sceletium resources have been depleted by over-harvesting and inadequate veld management.

Findings:

Recent research substantiates some traditional uses of Sceletium.
Alkaloid chemistry and pharmacological evidence are emerging, supporting potential applications.

Implications:

Sceletium shows promise for development as a dietary supplement and phytomedicine.
Further research into its alkaloid profile may lead to new drug discoveries.
Conservation of Sceletium resources is crucial for continued study and utilization.