Related Experiment Video
Updated: Jul 2, 2026

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Synthesis and properties of temperature-responsive chitosan by controlled free radical polymerization with
Jing Tang1, Daoben Hua, Jianxin Cheng
1Key Laboratory of Organic Synthesis of Jiangsu Province, School of Chemistry and Chemical Engineering, Suzhou University, 199 Renai Road, Suzhou 215123, PR China.
Abstract:
The temperature-responsive chitosan was synthesized by free radical polymerization of N-isopropylacrylamide (NIPAM) at 60 degrees C in the presence of RAFT-chitosan agent. The chitosan was subsequently modified with phthalic anhydride and with S-1-dodecyl-S'-(alpha,alpha'-dimethyl-alpha''-acetic acid) trithiocarbonate to serve as reversible addition fragmentation chain transfer (RAFT) agent. The polymerization results show that the graft polymerization proceeded via RAFT process, while the "well-defined" graft polymers were successfully synthesized. The temperature played an important role on the self-assembly in H2O dispersion and the morphologies of chitosan-g-PNIPAMs. To our knowledge, this is the first thermosensitive chitosan prepared from controlled graft modification of chitosan by RAFT polymerization.
More Related Videos
10:54Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
Published on: June 19, 2015
12:22Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
Related Concept Videos
Polymer Classification: Stereospecificity
Radical Chain-Growth Polymerization: Overview
Radical Chain-Growth Polymerization: Mechanism
Free-Radical Chain Reaction and Polymerization of Alkenes
Cationic Chain-Growth Polymerization: Mechanism
Radical Halogenation: Stereochemistry
Halogenation to form a new chiral center: