Palladium-catalyzed method for the synthesis of carbazoles via tandem C-H functionalization and C-N bond formation
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Updated: Jul 2, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
W C Peter Tsang1, Rachel H Munday, Gordon Brasche
1Department of Chemistry, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA.
Abstract:
The development of a new method for the assembly of unsymmetrical carbazoles is reported. The strategy involves the selective intramolecular functionalization of an arene C-H bond and the formation of a new arene C-N bond. The substitution pattern of the carbazole product can be controlled by the design of the biaryl amide substrate, and the method is compatible with a variety of functional groups. The utility of the new protocol was demonstrated by the concise synthesis of three natural products from commercially available materials.
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