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Updated: Jul 2, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Probing the structure of single-molecule surface-enhanced Raman scattering hot spots
Jon P Camden1, Jon A Dieringer, Yingmin Wang
1Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
Abstract:
We present here a detailed study of the specific nanoparticle structures that give rise to single-molecule surface-enhanced Raman scattering (SMSERS). A variety of structures are observed, but the simplest are dimers of Ag nanocrystals. We chose one of these structures for detailed study using electrodynamics calculations and found that the electromagnetic SERS enhancement factors of 10(9) are easily obtained and are consistent with single-molecule SERS activity.
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