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Updated: Jul 2, 2026
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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
Published on: June 4, 2020
Validation of thromboelastometry in horses
Saverio Paltrinieri1, Cecilia Meazza, Alessia Giordano
1Department of Veterinary Pathology, Hygiene and Public Health, Unit of General Pathology and Parasitology, University of Milan, Milan, Italy. saverio.paltrinieri@unimi.it
Veterinary Clinical Pathology
|September 3, 2008
Summary
This study validates the Rotem-gamma thromboelastometer for equine blood, defining the normal equine thromboelastogram. Results show variations based on horse type and exercise, with hemolysis and refrigeration impacting findings.
Area of Science:
- Veterinary Hematology
- Coagulation Science
Background:
- Thromboelastometry is crucial for diagnosing coagulation disorders but lacks validation in horses.
- The specific characteristics of equine thromboelastograms are not well-documented.
Purpose of the Study:
- To validate the Rotem-gamma thromboelastometer for equine blood analysis.
- To establish reference ranges for the normal equine thromboelastogram.
Main Methods:
- Utilized a Rotem-gamma thromboelastometer with 38 equine blood samples.
- Investigated native coagulation, intrinsic/extrinsic pathways, fibrinogen function, and fibrinolysis.
- Assessed method imprecision, hemolysis, and storage effects (time/temperature).
Main Results:
- Analytical imprecision was below 10% for the Rotem-gamma system.
- Equine thromboelastograms showed similarities to other species, with distinct pathway efficiencies.
- Reference intervals differed between saddle and racing horses, influenced by exercise and RBC mass.
Conclusions:
- The Rotem-gamma thromboelastometer is precise for equine blood.
- Equine thromboelastogram reference intervals are influenced by horse aptitude and exercise.
- Hemolysis and sample refrigeration significantly alter results.
