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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

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Updated: Jul 2, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Acute hepatitis C virus infection.

W L Irving1, D Salmon, C Boucher

  • 1Executive Committee, Viral Hepatitis Study Group, European Society for Clinical Microbiology and Infectious Diseases, Basel, Switzerland. Will.Irving@nottingham.ac.uk

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|September 3, 2008
PubMed
Summary
This summary is machine-generated.

About 25% of hepatitis C virus (HCV) infections clear spontaneously. This article highlights concerns regarding acute HCV infection, advocating for increased public health focus on this critical phase to manage the HCV epidemic.

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Last Updated: Jul 2, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection poses significant health risks, including liver disease, cirrhosis, and cancer.
  • While chronic HCV is well-studied, acute HCV infection remains poorly understood.
  • Spontaneous clearance occurs in approximately 25% of infected individuals.

Purpose of the Study:

  • To highlight critical concerns surrounding acute hepatitis C virus infection.
  • To advocate for a shift in public health resources towards addressing acute HCV.
  • To improve the management of the ongoing HCV epidemic.

Main Methods:

  • Review of existing literature on acute and chronic HCV infection.
  • Analysis of epidemiological data and clinical outcomes.
  • Synthesis of public health strategies for viral epidemics.

Main Results:

  • The majority of HCV infections progress to chronic disease.
  • Knowledge gaps persist regarding the pathogenesis and clinical course of acute HCV.
  • Current public health efforts may not adequately address the acute phase of HCV infection.

Conclusions:

  • Acute HCV infection warrants greater attention and research.
  • Public health bodies should reallocate resources to better manage acute HCV.
  • Enhanced focus on acute HCV could improve overall epidemic control and patient outcomes.