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Updated: Jul 2, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis
H D Hollis Showalter1, William A Denny
1Department of Medicinal Chemistry, University of Michigan, 428 Church St., Ann Arbor, MI 48109-1965, USA. showalh@umich.edu
Abstract:
Drug discovery and development, from an initial disease treatment concept to a new drug application (NDA), is a complex, lengthy and expensive process. In this review we discuss the key stages of drug discovery and early development, including target identification and validation, assay development and screening, confirmed hits to leads, lead optimization, and progressing development candidates to an investigational new drug (IND) filing. We also provide particular examples of how this process is beginning to assist in the development of small molecule treatments for tuberculosis, by summarizing the status of the clinical development of several newer classes of drugs. These include the fluoroquinolones, oxazolidinones, diarylquinolines, and nitroimidazo-oxazoles and -oxazines.
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