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Related Concept Videos

Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
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Export of Misfolded Proteins out of the ER01:32

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Cathepsin D: a cellular roadmap.

Nousheen Zaidi1, Andreas Maurer, Sebastian Nieke

  • 1Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmerlreich 7, 72074 Tubingen, Germany.

Biochemical and Biophysical Research Communications
|September 3, 2008
PubMed
Summary
This summary is machine-generated.

This review details the cellular journey of Cathepsin D, a key lysosomal enzyme. It covers its creation, modifications, and maturation within lysosomes in mammals.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Cathepsin D is a vital aspartic protease present in mammalian lysosomes.
  • It plays crucial roles in cellular processes, including protein degradation and turnover.

Purpose of the Study:

  • To comprehensively review the cellular life cycle of Cathepsin D.
  • To elucidate its biosynthesis, post-translational modifications, lysosomal targeting, and maturation.

Main Methods:

  • Literature review of existing research on Cathepsin D.
  • Analysis of studies detailing protein synthesis and modification pathways.
  • Examination of lysosomal trafficking and proteolytic processing mechanisms.

Main Results:

  • Cathepsin D undergoes complex co-translational and post-translational modifications.
  • Specific signaling pathways ensure its accurate targeting to lysosomes.
  • Proteolytic cleavage within lysosomes is essential for its functional maturation.

Conclusions:

  • Cathepsin D's cellular journey involves intricate regulatory steps from synthesis to maturation.
  • Understanding these processes is key to comprehending lysosomal function and associated pathologies.