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[Eosinophilia-myalgia syndrome]
J P Sieb1, T Scholten, S Beyenburg
1Neurologische Klinik, Universität Bonn.
Der Nervenarzt
|June 1, 1991
Summary
L-tryptophan supplementation, particularly from Showa Denko, has been linked to chronic eosinophilia-myalgia syndrome (EMS). This case highlights severe myalgia, muscle weakness, and skin changes associated with EMS.
Area of Science:
- Clinical Medicine
- Toxicology
Background:
- Eosinophilia-myalgia syndrome (EMS) is a serious condition.
- L-tryptophan supplements were widely used for sleep disorders.
Observation:
- A 62-year-old woman developed severe myalgia and muscle weakness after taking L-tryptophan from Showa Denko.
- Blood tests revealed elevated white blood cells and eosinophils.
- Bone marrow showed increased granulopoiesis and eosinophils.
- Muscle biopsy indicated inflammatory myopathy.
Findings:
- Prednisone treatment normalized eosinophil counts.
- Slow improvement in myalgia and general condition occurred without further immunosuppression.
- Hyperpigmented, scleroderma-like skin changes developed distally.
Implications:
- This case underscores the potential neurotoxic and systemic effects of contaminated L-tryptophan.
- Highlights the importance of vigilant monitoring for adverse drug reactions.
- Suggests a link between specific L-tryptophan manufacturing processes and EMS development.