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Related Concept Videos

Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbes in the Production of Fermented Foods01:27

Microbes in the Production of Fermented Foods

Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...

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Related Experiment Video

Updated: Jul 2, 2026

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
08:38

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

Do you have a probiotic in your future?

Maria G Dominguez-Bello1, Martin J Blaser

  • 1Department of Biology, University of Puerto Rico, USA. mgdbello2@gmail.com

Microbes and Infection
|September 3, 2008
PubMed
Summary
This summary is machine-generated.

Developing effective probiotics relies on understanding the human microbiome. Advances in metagenomics and host-microbe interactions pave the way for new probiotic strategies and clinical trials.

More Related Videos

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
09:49

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

Related Experiment Videos

Last Updated: Jul 2, 2026

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
08:38

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
09:49

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

Area of Science:

  • Microbiology and Human Health

Background:

  • The therapeutic potential of microbes for health maintenance and disease prevention is ancient.
  • Limited understanding of the human microbiome's composition and microbial biological requirements has hindered probiotic development.

Purpose of the Study:

  • To outline how advances in microbiome and metagenome research can establish a scientific basis for developing effective probiotic strategies.

Main Methods:

  • Leveraging advances in understanding the human microbiome and its metagenome.
  • Investigating intramicrobial competition and cooperation.
  • Analyzing host-microbe cross-signaling pathways.

Main Results:

  • Emerging knowledge provides a foundation for designing novel probiotics.
  • Understanding microbial interactions and signaling is key to successful probiotic deployment.

Conclusions:

  • Enhanced knowledge of the microbiome facilitates the design and modeling of probiotics.
  • This scientific progress is crucial for advancing towards clinical trials for probiotic therapies.