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Updated: Jul 2, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Imaging features of peripheral primitive neuroectodermal tumours.

S Hari¹, T P Jain, S Thulkar

¹Department of Radiology, IRCH, All India Institute of Medical Sciences, New Delhi, 110029, India.

The British Journal of Radiology

|September 3, 2008

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Primitive neuroectodermal tumours (PNETs) are aggressive cancers. This essay details imaging for rare extracranial PNETs, focusing on chest wall presentations.

Area of Science:

Oncology
Radiology
Pathology

Background:

Primitive neuroectodermal tumours (PNETs) are rare, aggressive small round cell neoplasms.
Most PNETs arise in the central nervous system, but extracranial (peripheral) PNETs also occur.
The chest wall is the most frequent site for peripheral PNETs, with established imaging characteristics.

Purpose of the Study:

To illustrate the diverse imaging features of primitive neuroectodermal tumours (PNETs) in extracranial locations.
To highlight the importance of recognizing PNETs in the differential diagnosis of chest wall masses.

Main Methods:

This is a pictorial essay.
It reviews imaging findings of PNETs at various extracranial sites.
Emphasis is placed on chest wall PNETs.

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Last Updated: Jul 2, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Main Results:

PNETs can occur in various extracranial locations, including the chest wall.
Imaging findings can be variable but share features with central nervous system PNETs.
Recognition of characteristic imaging patterns aids in diagnosis.

Conclusions:

Extracranial primitive neuroectodermal tumours (PNETs) are rare but important to diagnose.
Radiological assessment is crucial for identifying PNETs in diverse extracranial locations.
This essay provides a visual guide to the imaging of these aggressive neoplasms.