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Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO
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Mutational analysis of the structure basis for the multimerization function of NifA central domain

C Yang1, G Yu, S Shen

  • 1Laboratory of Molecular Genetics, Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, 200032, Shanghai, China.

Science in China. Series C, Life Sciences
|September 3, 2008
PubMed
Summary

The Thr-290 residue in Klebsiella pneumoniae NifA is crucial for activating nif gene transcription. This study confirms the NifA central domain mediates protein multimerization, identifying residues 252-453 as key for this function.

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