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Related Experiment Video

Updated: Jul 2, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Myeloneuropathy in a dentist.

Leif E Meyers¹, Bryan S Judge

¹Grand Rapids MERC/Michigan State University Program in Emergency Medicine, Grand Rapids, MI, USA.

Clinical Toxicology (Philadelphia, Pa.)

|September 3, 2008

Summary

A dentist developed myeloneuropathy from frequent nitrous oxide exposure. Treatment with vitamin B12 and l-methionine led to complete spinal cord signal regression on MRI.

Area of Science:

Neurology
Toxicology
Occupational Health

Background:

Nitrous oxide (N2O) is an anesthetic agent used in dentistry.
Chronic exposure to N2O can lead to neurological complications, including myeloneuropathy.
Occupational exposure in dental professionals is a potential risk factor.

Observation:

A 49-year-old male dentist presented with myeloneuropathy.
He reported frequent occupational use of nitrous oxide.
Spinal MRI revealed T2 hyperintensity in the posterior columns, indicative of myelopathy.

Findings:

The patient received treatment with vitamin B12 and l-methionine.
A follow-up MRI after 3 months showed complete resolution of the spinal cord lesions.
This suggests a reversible cause of myeloneuropathy.

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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

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Published on: February 13, 2018

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

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Published on: April 26, 2012

Implications:

Highlights the neurotoxic potential of chronic nitrous oxide exposure in dental practice.
Emphasizes the importance of early diagnosis and treatment for N2O-induced myeloneuropathy.
Suggests vitamin B12 and l-methionine as effective therapeutic agents for this condition.