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Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
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Human Melia azedarach poisoning.

Dong Haur Phua1, Wei-Jen Tsai, Jiin Ger

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|September 3, 2008
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Summary
This summary is machine-generated.

Melia azedarach (Ku-lian) poisoning in humans is rare but can cause significant neurological effects. Fortunately, supportive care led to full recovery in all reported cases.

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Area of Science:

  • Toxicology
  • Ethnobotany
  • Clinical Medicine

Background:

  • Melia azedarach (Ku-lian) is traditionally used in Chinese medicine for antiparasitic and antifungal purposes.
  • While its toxicity is documented in veterinary medicine, human poisoning cases are infrequently reported.
  • This study highlights five cases of human Melia azedarach poisoning.

Purpose of the Study:

  • To report on human poisoning cases from Melia azedarach (Ku-lian) ingestion.
  • To describe the clinical manifestations and outcomes of human Melia azedarach poisoning.
  • To emphasize the importance of supportive care in managing Melia azedarach toxicity.

Main Methods:

  • Retrospective review of cases from the Taiwan National Poison Center database.
  • Inclusion of both on-site patients and telephone consultations.
  • Analysis of clinical symptoms, treatment, and patient outcomes.

Main Results:

  • Neurological symptoms, including weakness, myalgia, numbness, and ptosis, were the predominant manifestations in four out of five patients.
  • The onset of symptoms varied significantly, from a few hours to three weeks post-ingestion.
  • All five patients recovered fully without any long-term sequelae following symptomatic and supportive treatment.

Conclusions:

  • Melia azedarach poisoning can present with diverse effects, including gastrointestinal, cardiovascular, respiratory, and neurological symptoms, with potential for fatality in severe instances.
  • The specific limonoids responsible for human toxicity remain unidentified.
  • Prompt recognition and supportive management are crucial for favorable outcomes in human Melia azedarach poisoning cases.