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Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm

L Smallwood1, R Allcock, F van Bockxmeer

  • 1Schools of Surgery, University of Western Australia, Fremantle, Western Australia.

The British Journal of Surgery
|September 3, 2008
PubMed
Abstract

Insights

Genetic variants in the matrix metalloproteinase (MMP)-9 gene were not associated with abdominal aortic aneurysm (AAA) in this study. Higher serum MMP-9 levels in AAA patients did not reach statistical significance.

Area of Science:

  • Genetics
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Matrix metalloproteinase (MMP)-9 activity is linked to abdominal aortic aneurysm (AAA) development.
  • Investigating the role of MMP-9 gene variants in AAA pathogenesis is crucial.

Purpose of the Study:

  • To explore the association between functional variants of the MMP-9 gene and abdominal aortic aneurysm (AAA).

Main Methods:

  • Genotyping of MMP-9 gene variants (-1562C > T and -1811A > T) in 678 AAA cases and 659 controls.
  • Measurement of serum MMP-9 levels in a subset of participants.
  • Assessment of genetic variants and haplotypes association with AAA using multivariable logistic regression.

Main Results:

  • No significant association was found between MMP-9 genotypes/haplotypes and AAA.
  • Serum MMP-9 concentrations were higher in AAA cases than controls, but not statistically significant.
  • Minor allele carriers showed higher serum MMP-9 levels, though not statistically significant.

Conclusions:

  • The genetic predisposition for elevated circulating MMP-9 levels is not associated with abdominal aortic aneurysm (AAA).
  • Further research may be needed to fully elucidate the role of MMP-9 in AAA pathogenesis.

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