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Updated: Jul 2, 2026

A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs
Published on: February 2, 2024
Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from
Naoyuki Kotoku1, Atsushi Hiramatsu, Hiroaki Tsujita
1Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Abstract:
A structure-activity relationship (SAR) study of bastadin 6 (1), a brominated tyrosine-derived metabolite from Indonesian marine sponge having a potent anti-angiogenic activity, was executed. The syntheses and their biological evaluation of the oxime-modified analogues and bromine-modified analogues revealed that both the oxime moieties and bromine atoms in bastadin 6 (1) play an important role to show the potent and selective anti-proliferative activity against human umbilical vein endothelial cells (HUVECs).
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