Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Electrochemical Gradient and Channel Proteins: An Overview01:21

Electrochemical Gradient and Channel Proteins: An Overview

An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell.  This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
Membrane Asymmetry Regulating Transporters01:19

Membrane Asymmetry Regulating Transporters

Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Childhood neglect, abuse, and their combination are differentially associated with specific emotion regulation and mental health issues.

Communications psychology·2026
Same author

Ribosomal RNA synthesis by RNA polymerase I is subject to premature termination of transcription.

eLife·2026
Same author

Simultaneous Profiling of Transcripts and Genomic Regions Associated with Nuclear Bodies Using the RNA-DNA High-Salt Recovered Sequence (RD-HRS) Method.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Predicting attractors from spectral properties of stylized gene regulatory networks.

Physical review. E·2023
Same author

Information-Theoretic Approaches in EEG Correlates of Auditory Perceptual Awareness under Informational Masking.

Biology·2023
Same author

Investigating the influence of masker and target properties on the dynamics of perceptual awareness under informational masking.

PloS one·2023

Related Experiment Video

Updated: Jul 2, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

Cellular automata approach of transmembrane ionic currents.

Laurent Pezard1, Annick Lesne

  • 1Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6149, Université de Provence - Marseille Cedex 3, France. laurent.pezard@univ-provence.fr

Journal of Integrative Neuroscience
|September 4, 2008
PubMed
Summary

This study introduces a cellular automata framework to model ionic currents in the brain. This approach helps understand brain electrophysiology and local electromagnetic fields from cellular to macroscopic levels.

More Related Videos

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
11:08

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device

Published on: September 19, 2025

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
10:50

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Related Experiment Videos

Last Updated: Jul 2, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
11:08

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device

Published on: September 19, 2025

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
10:50

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Area of Science:

  • Neuroscience
  • Computational Biology
  • Electrophysiology

Background:

  • Ionic currents across neuron and glial cell membranes are fundamental to brain electrophysiology.
  • These currents underpin functional brain dynamics and macroscopic phenomena like extracellular fields.
  • Relating cellular electrophysiology to macroscopic dipole models requires understanding elementary ionic motions.

Purpose of the Study:

  • To propose a general cellular automata framework for investigating ionic current distribution.
  • To model ionic motion in heterogeneous media with membranes.
  • To explore the derivation of local electromagnetic fields from ionic currents.

Main Methods:

  • Development of a general cellular automata framework.
  • Simulation of ionic motion in heterogeneous media.
  • Analysis of ionic current distribution and resulting electromagnetic fields.

Main Results:

  • The framework allows for the investigation of ionic current distribution in complex media.
  • The model provides a basis for understanding the link between cellular electrophysiology and macroscopic fields.
  • Local electromagnetic fields can be derived from the simulated ionic motions.

Conclusions:

  • The proposed cellular automata framework offers a novel approach to multi-scale modeling in neuroscience.
  • This model facilitates the connection between cellular-level ionic currents and macroscopic brain activity.
  • The framework is essential for deriving robust features and envisioning multi-scale approaches in brain research.