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Updated: Jul 2, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis
Heidi R Bokesch1, Antony Wamiru, Stuart F J Le Grice
1Molecular Targets Development Program, SAIC-Frederick, Inc., Frederick, Maryland 21702, USA.
Abstract:
Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in vitro with IC50 values of 1.46, >18, and 1.19 microM, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1 RT, none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 microg/mL).
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