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Related Concept Videos

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Organization of Genes02:07

Organization of Genes

Overview
Organization of Genes02:07

Organization of Genes

Overview

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Invariant nonequilibrium dynamics in gene regulation optimize information flow.

Proceedings of the National Academy of Sciences of the United States of America·2026
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Searching for sequence features that control DNA cyclizability.

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The FlEye camera: Sampling the joint distribution of natural scenes and motion.

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Long-term evolution of regulatory DNA sequences. Part 1: simulations on global, biophysically-realistic genotype-phenotype maps.

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Long-term evolution of regulatory DNA sequences. Part 2: theory and future challenges.

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Related Experiment Video

Updated: Jul 2, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

Information capacity of genetic regulatory elements.

Gasper Tkacik1, Curtis G Callan, William Bialek

  • 1Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey 08544, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|September 4, 2008
PubMed
Summary

This study uses information theory to show that gene regulatory elements can reliably transmit information despite cellular noise. Realistic models demonstrate that genetic computations can achieve capacities greater than one bit.

Failed At:

2026-06-19T13:36:12.932202+00:00

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