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Related Concept Videos

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Propagation of Waves01:07

Propagation of Waves

When a wave propagates from one medium to another, part of it may get reflected in the first medium, and part of it may get transmitted to the second medium. In such a case, the interface of the two mediums can be considered as a boundary that is neither fixed nor free.
Consider a scenario where a wave propagates from a string of low linear mass density to a string of high linear mass density. In such a case, the reflected wave is out of phase with respect to the incident wave, however the...
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
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Interference: Path Lengths01:10

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Consider two sources of sound, that may or may not be in phase, emitting waves at a single frequency, and consider the frequencies to be the same.
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Interference and Diffraction02:18

Interference and Diffraction

Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.
Propagation of Action Potentials01:23

Propagation of Action Potentials

The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
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Related Experiment Video

Updated: Jul 2, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

Long-range interaction effects on calcium-wave propagation.

W D Kepseu1, P Woafo

  • 1Laboratory of Modeling and Simulation in Engineering and Biological Physics, Faculty of Science, University of Yaounde I, PO Box 812, Yaounde, Cameroon.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|September 4, 2008
PubMed
Summary
This summary is machine-generated.

Numerical simulations reveal that long-range paracrine signaling affects calcium wave propagation speed and transition zones in cell networks. Bidirectional coupling minimizes these effects, unlike one-directional coupling, impacting pathogenic microorganism colonization dynamics.

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Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
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Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
09:34

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Published on: January 7, 2019

Area of Science:

  • Cellular biology
  • Biophysics
  • Mathematical modeling

Background:

  • Calcium waves are crucial for cellular communication and function.
  • Paracrine signaling involves cell-to-cell communication via extracellular messengers.
  • Understanding wave propagation in coupled cell networks is vital for biological processes.

Purpose of the Study:

  • To investigate the impact of long-range paracrine signaling on calcium wave dynamics in a coupled cell network.
  • To analyze the differences in wave propagation under bidirectional versus one-directional coupling.
  • To explore the influence of calcium wave propagation on pathogenic microorganism colonization.

Main Methods:

  • Numerical simulations of calcium wave propagation.
  • Modeling of cell networks with long-range paracrine interactions.
  • Analysis of wave frequency, amplitude, speed, and transition zones.

Main Results:

  • Long-range interactions significantly influence calcium wave speed and transition zone width.
  • Bidirectional coupling showed no effect on oscillation frequency or amplitude, unlike one-directional coupling.
  • The study explored long-range effects on pathogenic microorganism colonization dynamics within the network.

Conclusions:

  • Long-range paracrine signaling plays a critical role in modulating calcium wave propagation characteristics.
  • Coupling directionality is a key factor determining the influence of long-range interactions.
  • These findings have implications for understanding cellular communication and disease dynamics.