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Updated: Jul 2, 2026

Studying DNA Looping by Single-Molecule FRET
Published on: June 28, 2014
Impact of loop statistics on the thermodynamics of RNA folding
Thomas R Einert1, Paul Näger, Henri Orland
1Physik Department, Technische Universität München, 85748 Garching, Germany.
Abstract:
Loops are abundant in native RNA structures and proliferate close to the unfolding transition. By including a statistical weight approximately l(-c) for loops of length l in the recursion relation for the partition function, we show that the heat capacity depends sensitively on the presence and value of the exponent c, even for a short explicit tRNA sequence. For long homo-RNA, we analytically calculate the critical temperature and critical exponents which exhibit a nonuniversal dependence on c.
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