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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Emerging oral drugs for multiple sclerosis.

Claudio Gasperini1, Luca Ausili Cefaro, Giovanna Borriello

  • 1S Camillo-Forlanini Hospital, Department of Neuroscience, Viale dell'Università 30, 00185 Rome, Italy.

Expert Opinion on Emerging Drugs
|September 4, 2008
PubMed
Summary

New oral therapies show promise for multiple sclerosis (MS) treatment, offering alternatives to existing injectables. Further Phase III trials are needed to confirm their safety and efficacy as first-line or add-on treatments.

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Area of Science:

  • Neurology
  • Immunology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) treatment has advanced, with disease-modifying therapies improving outcomes for relapsing/remitting and secondary progressive MS.
  • Current injectable treatments offer partial efficacy and can cause side effects, leading to poor adherence.
  • There is a need for novel oral therapeutic approaches for MS management.

Purpose of the Study:

  • To review emerging oral drugs for multiple sclerosis (MS).
  • To present promising results from recent clinical trials of novel oral MS therapies.

Main Methods:

  • Review of current and novel oral treatment approaches for MS.
  • Analysis of data primarily from Phase I/II clinical trials.
  • Emphasis on the need for Phase III trial data to confirm safety and efficacy.

Main Results:

  • Several oral agents, including fingolimod, fumaric acid, cladribine, teriflunomide, and laquinomid, have shown promising results.
  • These studies evaluated the safety and efficacy of the new oral therapies.
  • Pivotal reports indicate potential benefits of these emerging treatments.

Conclusions:

  • The suitability of these oral drugs as first-line MS treatment depends on their safety profiles.
  • Oral therapies may serve as add-on treatments for patients unresponsive to first-line therapy.
  • These agents could also function as effective induction therapies in MS management.