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Updated: Jul 2, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Emerging drugs for adrenocortical carcinoma
Alfredo Berruti1, Anna Ferrero, Paola Sperone
1Department of Clinical and Biological Science, Oncologia Medica, University of Turin, Azienda Ospedaliera San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy. alfredo.berruti@gmail.com
Background:
Adrenocortical carcinoma (ACC) is an extremely rare aggressive disease. Few data are available on the efficacy of systemic antineoplastic treatments (mitotane and cytotoxic therapy) in the treatment of advanced disease.
Objective/Methods:
this paper will review the existing treatment strategies and new perspectives in the management of ACC patients.
Results/Conclusion:
An ongoing randomized international trial aims to define the best combination chemotherapy plus mitotane regimen. Based on the results of a case control study, mitotane is being explored as adjuvant therapy. Genetic and biological studies have identified molecular targets for specific targeted drugs such as IGF receptor inhibitors and antiangiogenetic drugs. Phase II trials are exploring the activity of these drugs either alone or in combination with chemotherapy.
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