Related Experiment Video

Updated: Jul 2, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

Emerging drugs for the prevention of bronchopulmonary dysplasia

Anne Greenough1

  • 1Division of Asthma, Allergy and Lung Biology, King's College Hospital, Denmark Hill, London, SE5 9RS, UK. anne.greenough@kcl.ac.uk

Expert Opinion on Emerging Drugs
|September 4, 2008
PubMed

Insights

Preventing bronchopulmonary dysplasia (BPD) in premature infants is crucial. While early corticosteroids and Vitamin A show promise, they have side effects, necessitating further research for safer options.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Clinical Trials

Background:

  • Bronchopulmonary dysplasia (BPD) is a frequent complication in extremely premature infants.
  • BPD is linked to long-term respiratory problems in survivors.

Purpose of the Study:

  • To evaluate preventative therapies for BPD.
  • Focus on treatments proven safe and effective in randomized trials.

Main Methods:

  • A comprehensive literature review was performed.
  • Analysis of randomized controlled trials (RCTs) for BPD prevention.

Main Results:

  • Systemic corticosteroids in the first two weeks reduce BPD but carry significant risks.
  • Vitamin A also decreases BPD incidence but requires further dosage optimization due to side effects.
  • Emerging therapies like antioxidants, low-dose nitric oxide, and methylxanthines show potential.

Conclusions:

  • Safe and effective pharmacological prevention of BPD remains an unmet clinical need.
  • Additional research is required to establish optimal and safe treatment regimens.
Abstract

More Related Videos

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease04:21

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

Published on: August 4, 2021

Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...