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Non-exercising muscle metabolism during exercise.

J C McDermott1, G C Elder, A Bonen

  • 1Department of Physiology and Biophysics, Dalhouse University, Halifax, Nova Scotia, Canada.

Pflugers Archiv : European Journal of Physiology
|May 1, 1991
PubMed
Summary

Muscle glycogen decreases even in non-exercising muscles during exercise. This study found that degraded glycogen is not retained as metabolites, suggesting enhanced, uncoupled metabolism in these muscles.

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Area of Science:

  • Exercise Physiology
  • Muscle Metabolism
  • Biochemistry

Background:

  • Muscle glycogen depletion occurs during exercise, even in muscles not directly involved in locomotion.
  • The fate of this degraded glycogen in non-exercising muscles remains unclear.

Purpose of the Study:

  • To determine if glycogen degraded in non-exercising muscles is retained as glycolytic intermediates or effluxed.
  • To investigate glycogen metabolism and its relationship to energy demand in unloaded muscles during exercise.

Main Methods:

  • Hindlimb muscles were unloaded using a suspension harness during a 90-minute exercise bout.
  • Muscle glycogen and key glycolytic intermediates (glucose 6-phosphate, fructose 6-phosphate, fructose 1,6-bisphosphate, glycerol 3-phosphate, lactate) were measured.
  • On-line electromyography assessed muscle contractile activity.

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Main Results:

  • Similar glycogen decrements were observed in both exercising and non-exercising muscles.
  • Lactate concentrations increased in both muscle types, but glycolytic intermediates showed only slight changes.
  • Accumulated glycolytic intermediates and lactate accounted for only 15%-28% of the degraded glycogen in non-exercising muscles.

Conclusions:

  • Glycogen metabolism is enhanced in non-exercising muscles during exercise.
  • Glycogen utilization in these muscles is uncoupled from immediate energetic demands.
  • Mobilized glycogen is not retained within the non-exercising muscle as other metabolite pools.