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Updated: Jul 2, 2026
09:29
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Potentially curable metastatic colorectal cancer
Matthew Katz1, Jean-Nicolas Vauthey
1Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 444, Houston, TX 77030, USA.
Current Oncology Reports
|September 4, 2008
Summary
Advances in chemotherapy and surgery offer hope for metastatic colorectal cancer patients. Achieving a margin-negative resection is key for potentially curative treatment, even with poor prognostic factors.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Metastatic colorectal cancer historically presented a poor prognosis.
- Recent advancements offer potential for long-term survival and cure.
Purpose of the Study:
- To highlight innovative strategies and techniques for treating metastatic colorectal cancer.
- To emphasize the importance of multidisciplinary approaches for potentially curative resection.
Main Methods:
- Review of current chemotherapeutic advancements.
- Analysis of surgical techniques for complete tumor resection.
- Discussion of multidisciplinary treatment strategies.
Main Results:
- Multidisciplinary strategies including surgery can achieve safe resection of all metastatic disease with negative margins.
- Favorable outcomes can be predicted with these strategies.
- Poor prognostic factors do not preclude curative strategies if margin-negative resection is possible.
Conclusions:
- Innovative strategies can improve cure rates in metastatic colorectal cancer.
- Margin-negative resection is crucial for potentially curative treatment.
- Further research is needed to maximize cure rates.
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