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Evaluation of left atrial longitudinal function in patients with hypertrophic cardiomyopathy: a tissue Doppler

I A Paraskevaidis1, F Panou, C Papadopoulos

  • 1Second Department of Cardiology, Athens University Medical School, Attiko University Hospital, Athens, Greece. iparas@otenet.gr

Heart (British Cardiac Society)
|September 4, 2008
PubMed

Insights

Left atrial function is reduced in hypertrophic cardiomyopathy (HCM). Two-dimensional (2D) strain analysis improves differentiation of HCM from other conditions and is more efficient than tissue Doppler imaging (TDI).

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Assessing left atrial (LA) function is crucial for understanding cardiac health.
  • Traditional methods may not fully capture subtle changes in LA function.

Purpose of the Study:

  • To quantify left atrial longitudinal function using tissue Doppler imaging (TDI) and 2D strain in patients with HCM.
  • To compare the diagnostic and practical utility of TDI and 2D strain for assessing LA function in HCM.
  • To evaluate the additive prognostic value of atrial strain in differentiating HCM from other forms of left ventricular hypertrophy (LVH).

Main Methods:

  • A case-control study involving patients with familial HCM, non-HCM LVH, and healthy controls.
  • Utilized both TDI and 2D strain echocardiography to assess LA longitudinal function across all atrial phases (reservoir, conduit, contractile).
  • Measured left ventricular systolic strain and total atrial deformation (TAD).

Main Results:

  • Both TDI and 2D strain revealed significantly reduced LA function in HCM patients compared to controls across all atrial phases.
  • Two-dimensional (2D) contractile atrial strain significantly enhanced the prognostic value in differentiating HCM from non-HCM LVH when added to conventional echocardiographic parameters.
  • 2D strain demonstrated higher reproducibility and significantly shorter processing times compared to TDI in HCM patients.

Conclusions:

  • Left atrial longitudinal function is demonstrably impaired in patients with HCM.
  • Two-dimensional (2D) strain analysis offers a valuable, reproducible, and time-efficient method for assessing LA function and differentiating HCM.
  • 2D strain provides additive prognostic information, aiding in the clinical management of HCM.
Abstract

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