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Updated: Jul 2, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
Cohesion by topology: sister chromatids interlocked by DNA
Rodrigo Bermejo1, Dana Branzei, Marco Foiani
1Fondazione Italiana per la Ricerca sul Cancro (FIRC) Institute of Molecular Oncology Foundation, 20139 Milan, Italy.
Abstract:
Sister chromatid cohesion is coupled with chromosome replication and influences chromosome segregation and intra-S repair. Specialized proteins, the cohesins, together with other pathways contribute to tether sister chromatids. In this issue of Genes & Development, Wang and colleagues (pp. 2426-2433 demonstrate that TopoIV, a type II DNA topoisomerase, modulates cohesion in Escherichia coli, by removing interlocked DNA junctions between sister chromatids. They propose that DNA precatenanes, arising during replication fork progression, hold sister chromatids together.
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