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Related Concept Videos

Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall of a...
Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall of a...
Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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Fimbriae, Pili, and Axial Filaments

Fimbriae and pili are specialized bacterial surface structures that play pivotal roles in adhesion, genetic exchange, and motility. Composed primarily of pilin protein, these hairlike appendages are crucial for bacterial survival and pathogenicity in various environments.Fimbriae: Adhesion and PathogenicityFimbriae are fine, filamentous structures measuring 2–10 nanometers in diameter and are densely distributed on the bacterial cell surface. They facilitate bacterial adhesion to abiotic...
Spindle Assembly02:50

Spindle Assembly

Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...
Spindle Assembly02:50

Spindle Assembly

Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
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Related Experiment Video

Updated: Jul 2, 2026

Microdissection of Black Widow Spider Silk-producing Glands
09:47

Microdissection of Black Widow Spider Silk-producing Glands

Published on: January 11, 2011

Spindly attachments.

Filiz Civril1, Andrea Musacchio

  • 1Department of Experimental Oncology, European Institute of Oncology, I-20139 Milan, Italy.

Genes & Development
|September 4, 2008
PubMed
Summary
This summary is machine-generated.

The Spindly/SPDL-1 protein is crucial for accurate chromosome attachment to spindle microtubules during cell division. This research illuminates its role in maintaining cell ploidy and controlling cell cycle progression.

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Self-Assembly of Microtubule Tactoids
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Self-Assembly of Microtubule Tactoids

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Last Updated: Jul 2, 2026

Microdissection of Black Widow Spider Silk-producing Glands
09:47

Microdissection of Black Widow Spider Silk-producing Glands

Published on: January 11, 2011

Optimizing Attachment of Human Mesenchymal Stem Cells on Poly(ε-caprolactone) Electrospun Yarns
10:50

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Self-Assembly of Microtubule Tactoids
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Self-Assembly of Microtubule Tactoids

Published on: June 23, 2022

Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • Accurate chromosome segregation is vital for eukaryotic cell ploidy maintenance during mitosis.
  • The process involves the precise attachment of chromosomes to spindle microtubules.

Discussion:

  • Gassmann and colleagues analyze the Spindly/SPDL-1 protein, a recently identified factor in mitosis.
  • This protein plays a significant role in chromosome-microtubule attachment.

Key Insights:

  • Spindly/SPDL-1 influences the fidelity of chromosome attachment to spindle fibers.
  • The protein's function is linked to the regulation of cell cycle progression.

Outlook:

  • Further research into Spindly/SPDL-1 could reveal new therapeutic targets for diseases involving aneuploidy.
  • Understanding this mechanism enhances our knowledge of fundamental cell division processes.