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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

Epilepsy ll: Types

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.

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Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

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Published on: October 17, 2025

Complicated relationship between autism with regression and epilepsy.

Hana Oslejsková¹, Ladislav Dusek, Zuzana Makovská

¹Department of Paediatric Neurology, Children's Medical Centre, University Hospital Brno, Czech Republic. hoslej@fnbrno.cz.

Neuro Endocrinology Letters

|September 4, 2008

Summary

Autistic regression is strongly linked to epilepsy, with seizures worsening IQ and functionality. Epilepsy influences regression

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Area of Science:

Developmental Neuroscience
Pediatric Neurology
Autism Spectrum Disorder Research

Background:

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition.
Regression, a loss of previously acquired skills, is a recognized subtype of ASD.
The relationship between autistic regression and epileptic processes requires further elucidation.

Purpose of the Study:

To investigate the association between autistic regression and epileptic disorders.
To determine the impact of epileptic seizures on cognitive and functional outcomes in children with regression.
To analyze how epilepsy influences the age of onset and clinical presentation of autistic regression.

Main Methods:

Retrospective evaluation of 205 children diagnosed with autism.
Comparison of a subset of 71 children with a history of regression against those without.
Analysis of epileptic processes, clinical seizures, and electroencephalogram (EEG) abnormalities.

Main Results:

Autistic regression showed a significant association with epileptic process symptoms.
Children with regression and epilepsy exhibited lower IQs (<70) and reduced functionality, exacerbated by clinical seizures.
Epileptic seizures were linked to later regression onset (median 35 months) and predominantly behavioral regression.

Conclusions:

Epileptic seizures are a significant comorbidity in children with autistic regression.
Clinical epileptic seizures, more than sub-clinical EEG abnormalities, correlate with diminished IQ and functionality.
Epilepsy impacts the timing and type of regression, particularly behavioral regression, in children with autism.