Related Experiment Video

Updated: Jul 2, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

[New respiratory viruses in children 2 months to 3 years old with recurrent wheeze]

Alberto F Maffey1, Carolina M Venialgo, Paola R Barrero

  • 1Centro Respiratorio, Hospital de Niños Dr. Ricardo Gutiérrez.

Archivos Argentinos De Pediatria
|September 4, 2008
PubMed

Insights

Respiratory viruses are common in infants and young children with recurrent wheeze, often leading to hospitalization. Respiratory Syncytial Virus and Rhinovirus were the most prevalent, highlighting the need for targeted interventions.

Area of Science:

  • Pediatrics
  • Virology
  • Infectious Diseases

Background:

  • Respiratory viruses frequently trigger exacerbations in infants and children.
  • Respiratory Syncytial Virus (RSV) is common in infants, while Rhinovirus affects children.

Purpose of the Study:

  • To determine the prevalence and epidemiological characteristics of respiratory viruses in young children with recurrent wheeze.
  • To identify common viral pathogens in hospitalized infants and children experiencing bronchial obstruction.

Main Methods:

  • A prospective, cross-sectional study included 119 children (2 months to 3 years) with recurrent wheeze and asthma risk factors.
  • Respiratory samples were analyzed using immunofluorescence and Polymerase Chain Reaction (PCR) for viral detection.
  • Detected viruses included Respiratory Syncytial Virus, Rhinovirus, Metapneumovirus, Influenza A, Enterovirus, Bocavirus, Adenovirus, Coronavirus, and Parainfluenza.

Main Results:

  • A high prevalence of respiratory viruses was found, with 86% of patients testing positive.
  • Respiratory Syncytial Virus (43%) and Rhinovirus (23%) were the most common viruses detected.
  • Coinfections were observed in 25% of cases, with single infections in 75%.

Conclusions:

  • Infants and young children hospitalized for bronchial obstruction with recurrent wheeze exhibit a high prevalence of respiratory viruses.
  • Viral circulation peaked during specific months, correlating with hospital admission rates.
  • These findings underscore the significant role of respiratory viruses in pediatric recurrent wheeze and asthma.
Abstract

More Related Videos

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...