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Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...

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Related Experiment Video

Updated: Jul 2, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
09:32

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

MHC motif viewer.

Nicolas Rapin1, Ilka Hoof, Ole Lund

  • 1Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.

Immunogenetics
|September 4, 2008
PubMed
Summary
This summary is machine-generated.

The MHC Motif Viewer is a new web tool that displays peptide-binding specificities for major histocompatibility complex (MHC) molecules. This resource helps researchers compare immune responses across species and identify specific epitopes.

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Published on: March 6, 2009

Area of Science:

  • Immunology
  • Bioinformatics
  • Genomics

Background:

  • Major Histocompatibility Complex (MHC) molecules present peptides to the immune system in vertebrates.
  • Human Leukocyte Antigens (HLAs) are human MHCs and are highly polymorphic, influencing individual immune responses.
  • Understanding MHC binding specificities is crucial for identifying epitopes and comparing immune variations.

Purpose of the Study:

  • To develop a web server for visualizing and comparing MHC molecule binding specificities.
  • To provide a tool for analyzing peptide-binding motifs across different species and MHC loci.
  • To facilitate the discovery of similarities and differences in MHC specificities.

Main Methods:

  • Development of the MHC Motif Viewer web server.
  • Inclusion of binding motif data for human HLA class I (A, B, C, E) and HLA-DR proteins.
  • Integration of MHC class I data for chimpanzee, rhesus monkey, and mouse.
  • Implementation of a 'MHC fight' feature for side-by-side comparison of two MHC molecule specificities.

Main Results:

  • The MHC Motif Viewer enables the display of likely binding motifs for a wide range of MHC class I and HLA-DR molecules.
  • The 'MHC fight' feature allows for direct comparison of binding specificities between different MHC molecules.
  • The tool successfully revealed both conserved and divergent binding specificities within and across species.

Conclusions:

  • The MHC Motif Viewer is a valuable resource for researchers studying immune response variations.
  • The tool aids in the identification of epitopes and understanding MHC restriction.
  • It provides a novel platform for comparative analysis of MHC specificities across species.