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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

CCN2 YAPs at cancer.

Andrew Leask1

  • 1CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Dental Sciences Building, University of Western Ontario, London, ON, N6A 5C1, Canada, Andrew.leask@schulich.uwo.ca.

Journal of Cell Communication and Signaling
|September 4, 2008
PubMed
Summary
This summary is machine-generated.

The YAP oncogene promotes cancer by activating CCN2 (connective tissue growth factor). CCN2 is a key mediator of YAP-driven tumor growth, confirming its oncogenic role.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • The YAP transcription coactivator is implicated as an oncogene amplified in human cancers.
  • CCN2 (connective tissue growth factor) is a known target of YAP and its transcription factor TEAD.
  • Previous studies established CCN2 as a downstream target of YAP in promoting tumor growth.

Purpose of the Study:

  • To investigate the role of CCN2 in mediating the growth-promoting functions of YAP.
  • To confirm CCN2 as a key oncogenic mediator in cancer.

Main Methods:

  • The study builds upon previous findings regarding YAP and CCN2 interaction.
  • Analysis of gene expression and protein interactions related to YAP and CCN2.
  • Review of data from Zhao et al. (Genes Dev 2008).

Main Results:

  • CCN2 plays a significant role in the growth-promoting activity of YAP.
  • The findings confirm CCN2 as a critical oncogenic mediator.
  • YAP-driven tumor growth is significantly influenced by CCN2 levels.

Conclusions:

  • CCN2 is a key mediator of YAP's oncogenic functions.
  • Targeting the YAP-CCN2 axis may offer therapeutic strategies for cancer.
  • Further research is warranted to explore the therapeutic potential of inhibiting this pathway.