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Related Experiment Video

Updated: Jul 2, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
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Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

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Improving image-guided target localization through deformable registration.

Kristy K Brock1, Maria Hawkins, Cynthia Eccles

  • 1Radiation Medicine Program, Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada. kristy.brock@rmp.uhn.on.ca

Acta Oncologica (Stockholm, Sweden)
|September 4, 2008
PubMed
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Radiology. Imaging cancer·2026

Deformable registration using kV cone beam CT (CBCT) significantly improves online target localization for liver cancer radiation therapy. This method accurately maps tumor position, reducing displacement errors for better treatment accuracy.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Image-Guided Therapy

Background:

  • Accurate online target localization is crucial in radiation therapy.
  • Liver motion and deformation can introduce significant uncertainties in tumor targeting.
  • kV cone beam CT (CBCT) is increasingly used for image guidance during treatment.

Purpose of the Study:

  • To quantify the improvements in online target localization for liver cancer radiation therapy.
  • To evaluate the effectiveness of deformable registration with kV CBCT.

Main Methods:

  • Twelve liver cancer patients underwent daily kV CBCT imaging during a 6-fraction protocol.
  • Rigid registration aligned the liver on CBCT to planning CT.
  • Deformable registration using the MORFEUS algorithm mapped the tumor onto daily CBCT images.

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  • Center of mass (COM) displacement of the tumor was calculated.

    • Main Results:

    • Mean COM displacement after deformable registration was minimal (0.08-0.10 cm) across directions.
    • Maximum displacements reached up to 0.97 cm in the superior-inferior direction.
    • 15% of fractions and 33% of patients showed COM displacement > 0.3 cm.
    • Deformable registration was rapid, averaging under 1 minute.

    Conclusions:

    • Deformable registration enhances online target localization accuracy in liver cancer radiotherapy.
    • While rigid registration is often sufficient, deformable methods account for liver deformation.
    • This technique offers improved precision for image-guided radiation therapy.