Clinical and pathological changes caused by the interaction of lasalocid and chloramphenicol in broiler chickens

Uncommon and abnormal gait, characterised by toe walking and progressive leg weakness, was observed in a large broiler flock in Israel. Identical clinical signs were reproduced when young chicks received feed supplemented with lasalocid (Abatec-Roche), and chloramphenicol at normal recommended levels, for 12 days or more. The clinical and pathological findings suggest a neuromuscular toxic effect of lasalocid-chloramphenicol interaction in broiler chicks. To our best knowledge this is the first report on the toxic effect caused by the combination of lasalocid and chloramphenicol.