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Related Experiment Video

Updated: Jul 2, 2026

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence

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Published on: October 11, 2018

Paralysis and lameness associated with aflatoxicosis in broilers.

J O Okoye¹, I U Asuzu, H C Gugnani

¹Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria.

Avian Pathology : Journal of the W.V.P.A

|January 1, 1988

Summary

Aflatoxicosis in broiler chickens caused neurological symptoms like paralysis and lameness. Histopathology revealed liver damage and lymphoid depletion, with Aspergillus flavus and Aflatoxin B1 identified in feed.

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Area of Science:

Veterinary Pathology
Mycotoxicology
Poultry Science

Background:

Aflatoxicosis, a disease caused by aflatoxins produced by Aspergillus species, is a significant concern in poultry production.
Clinical signs of aflatoxicosis can vary, but neurological manifestations are less commonly reported in broiler chickens.

Purpose of the Study:

To characterize two unusual cases of aflatoxicosis in broiler chickens presenting with distinct neurological signs.
To identify the causative agent and mycotoxin involved in these cases.
To correlate clinical signs with histopathological findings.

Main Methods:

Clinical examination of affected broiler chickens.
Necropsy and histopathological examination of liver, lymphoid organs, and nervous tissues.
Isolation and identification of fungal species from feed and litter.
Detection and quantification of Aflatoxin B1 in feed samples using analytical methods.

Main Results:

Affected broilers exhibited trembling, ataxia, leg and wing paralysis, and lameness.
Histopathology confirmed severe hepatocyte degeneration, bile duct proliferation, and lymphocyte depletion in lymphoid organs.
Aspergillus flavus was isolated from feed and litter; Aflatoxin B1 was detected at 2.4 mg/kg in one feed sample.

Conclusions:

These cases highlight an unusual presentation of aflatoxicosis in broilers with prominent neurological signs.
The findings underscore the importance of monitoring feed for Aspergillus contamination and aflatoxins to prevent such outbreaks.
Histopathological changes in the liver and lymphoid organs are consistent with mycotoxin toxicity.