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Updated: Jul 2, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
G--C quartet--a DNA-inspired Janus-GC heterocycle: synthesis, structural analysis, and self-organization
Ali Asadi1, Brian O Patrick, David M Perrin
1Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, B.C., V6T-1Z1, Canada.
Abstract:
In this communication we disclose the synthesis and characterization of a DNA-inspired self-complementary heterocycle that contains AAD-DAA H-bond acceptor/donor patterns. Whereas in the past such AAD-DAA self-complementarity has given rise to trimeric and hexameric rosettes, we now demonstrate that the same H-bonding scheme, when properly arrayed, can be used to program a tetrameric rosette, which unlike a G-quartet requires no metal binding or peripheral components for preorganization. Of note, we exploit both 2D-NOESY and DOSY 1H NMR to substantiate the tetrameric stoichiometry in this noncovalent rosette comprising 12 H-bonds.
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