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Updated: Jul 2, 2026
Skeletal Muscle Gender Dimorphism from Proteomics
Published on: December 14, 2011
2D difference gel electrophoresis of prepubertal and pubertal rat mammary gland proteomes
Helen Kim1, Mark B Cope, Richie Herring
1Departments of Pharmacology & Toxicology, the UAB Center for Nutrient-Gene Interaction, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. Helenkim@uab.edu
Abstract:
Rat mammary gland proteomes at day 21 (prepubertal) and day 50 (late puberty) were compared by 2D difference gel electrophoresis. Two-hundred fifty-one spots were significantly different ( p < 0.05) in abundance. Peptide mass fingerprint analysis of a subset of these proteins identified two significantly over-represented classes including structural and blood proteins (increased), and metabolism-relevant proteins (reduced) in day 50 relative to day 21 glands. This is a first report of mammary gland proteome differences at these important breast cancer-relevant time-points.
