Maximum likelihood techniques applied to method comparison studies
Related Experiment Videos
1School of Mathematics, University of Wales, College of Cardiff, U.K.
Statistics in Medicine
|June 1, 1991
Abstract:
One component of method comparison studies is the assessment of relative bias. Most authors use ordinary regression techniques for this purpose. The potential inadequacies in this approach are highlighted and a more generally applicable maximum likelihood technique proposed. The properties of the various methods of estimation are obtained by means of a simulation study, using a variety of different within-assay precision profiles.