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Toothpaste detergents: a potential source of oral soft tissue damage?
1Division of Restorative Dentistry, Dental School, Lower Maudlin Street, Bristol, UK. c.p.moore@bristol.ac.uk
International Journal of Dental Hygiene
|September 5, 2008
Summary
Toothpaste detergents can harm oral cells, with Sodium Lauryl Sulphate and others reducing cell viability. Pluronic, however, may stimulate cells, warranting further investigation into its effects on oral tissues.
Area of Science:
- Oral biology
- Cellular toxicology
Background:
- Toothpastes contain detergents that aid cleaning.
- These detergents may potentially damage oral soft tissues at a cellular level.
Purpose of the Study:
- To investigate the in vitro effects of common toothpaste detergents on oral mucosal cells.
Main Methods:
- TERT-1 keratinocytes were exposed to varying concentrations of Adinol, Sodium Lauryl Sulphate, Tego Betain, and Pluronic.
- Cell viability was assessed using an MTT assay after 24 hours of incubation.
Main Results:
- Adinol, Sodium Lauryl Sulphate, and Tego Betain significantly reduced cell viability in a dose-dependent manner.
- Pluronic demonstrated a stimulatory effect on cell viability compared to controls.
Conclusions:
- Certain toothpaste detergents may pose a risk of soft tissue damage to the oral mucosa.
- The stimulatory effect of Pluronic suggests a potential oxidative stress response requiring further research.
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