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Related Concept Videos

Instrument Calibration01:12

Instrument Calibration

Instrument calibration is essential for ensuring that instruments produce accurate and consistent results. It is vital in manufacturing, healthcare, testing laboratories, and scientific research. Calibration processes are specific to each instrument and help enhance data accuracy. Each instrument has a unique calibration process tailored to its design and function to improve data accuracy.
Analytical Balance Calibration
An analytical balance measures mass and requires regular calibration to...
Calibration Curves: Correlation Coefficient01:10

Calibration Curves: Correlation Coefficient

In a linear calibration curve, there is a value called the calibration coefficient, denoted by 'r,' which measures the strength and the direction of association between two variables. The correlation coefficient value ranges from −1 to +1. A value of +1 indicates a perfect positive linear correlation, −1 denotes a perfect negative correlation, and 0 implies no correlation between the two variables. A positive correlation value establishes that as one variable increases, the other increases, and...
Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Double calibration vs. global optimisation: performance and effectiveness for clinical application.

Rita Stagni1, Silvia Fantozzi, Angelo Cappello

  • 1Dipartimento di Elettronica, Informatica e Sistemistica, Università degli Studi di Bologna, Viale Risorgimento 2, 40136 Bologna, Italy. rita.stagni@unibo.it

Gait & Posture
|September 5, 2008
PubMed
Summary
This summary is machine-generated.

Soft tissue artefact (STA) significantly impacts joint kinematics analysis. Double calibration effectively reduces STA, offering superior accuracy for subject-specific motion quantification compared to global optimization methods.

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Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements
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Published on: September 7, 2019

Area of Science:

  • Biomechanics
  • Medical imaging
  • Orthopedics

Background:

  • Accurate subject-specific kinematics are crucial for clinical applications.
  • Soft tissue artefact (STA) propagation can compromise stereophotogrammetric analysis interpretability.
  • STA is highly dependent on the individual and the specific task.

Purpose of the Study:

  • To compare the efficacy of double calibration and global optimization in mitigating STA.
  • To evaluate the reduction of STA in knee joint kinematics using 3D fluoroscopy as a gold standard.

Main Methods:

  • Utilized 3D fluoroscopy as the gold standard for kinematic assessment.
  • Compared the performance of double calibration against global optimization techniques.
  • Quantified the propagation of soft tissue artefacts in knee joint kinematics.

Main Results:

  • Double calibration demonstrated significantly lower root mean square error (RMSE): 1-2 degrees for rotations and 1-3 mm for translations.
  • Global optimization exhibited higher RMSE: approximately 10 degrees for rotations and 10-15 mm for translations.
  • Double calibration proved highly effective in reducing STA propagation in experimental data.

Conclusions:

  • Double calibration is the preferred method for accurate subject-specific knee joint kinematics quantification.
  • The findings suggest double calibration enhances the clinical interpretability of motion analysis.
  • Reducing soft tissue artefact is essential for reliable biomechanical assessments.