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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jul 2, 2026

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Plant microRNA detection using the circular code information.

Ahmed Ahmed1, Christian J Michel

  • 1Equipe de Bioinformatique Théorique, LSIIT (UMR CNRS-ULP 7005), Université Louis Pasteur de Strasbourg, Pôle API, Illkirch, France. ahmed@dpt-info.u-strasbg.fr

Computational Biology and Chemistry
|September 5, 2008
PubMed
Summary
This summary is machine-generated.

Researchers identified a novel property in plant microRNAs based on circular code information. This discovery enables precise detection of microRNAs in plants using gene sequence analysis.

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Last Updated: Jul 2, 2026

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Published on: November 14, 2019

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Discrimintion and Mapping of the Primary and Processed Transcripts in Maize Mitochondrion Using a Circular RT-PCR-based Strategy

Published on: July 29, 2019

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • Plant microRNAs play crucial roles in gene regulation.
  • Identifying microRNAs is essential for understanding plant biology and development.
  • Existing methods for microRNA identification have limitations.

Purpose of the Study:

  • To introduce a new computational method for identifying plant microRNAs.
  • To leverage a newly discovered property of microRNAs based on circular code information.
  • To improve the accuracy and efficiency of microRNA detection in plants.

Main Methods:

  • Developed a computational method utilizing the C(3) circular code.
  • The C(3) circular code is a set of 20 trinucleotides found in gene reading frames.
  • Applied a sliding window approach of 14 nucleotides for detection.

Main Results:

  • Identified a new property in plant microRNAs linked to the C(3) circular code.
  • The C(3) circular code was detected near the start of microRNAs.
  • The method demonstrated sensible and precise microRNA site identification.

Conclusions:

  • The C(3) circular code property offers a novel approach for plant microRNA identification.
  • This method relies solely on the internal gene structure, enhancing specificity.
  • The findings contribute to more accurate and efficient microRNA discovery in plants.