Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

Median parameters for Down's syndrome screening should be calculated using a moving time-window method.

T M Reynolds¹, J Aldis

¹Clinical Chemistry Department, Queen's Hospital, Belvedere Road, Burton-on-Trent, Staffordshire DE13 0RB. Tim.Reynolds@Burtonh-tr.wmids.nhs.uk

Annals of Clinical Biochemistry

|September 5, 2008

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Serum uric acid and new-onset hypertension: a possible therapeutic avenue?

Journal of human hypertension·2014

Same author

Targeted lipid treatment: decades of failure suggest new targets are in order.

International journal of clinical practice·2013

Same author

Prescribing high-dose lipid-lowering therapy early to avoid subsequent cardiovascular events: is this a cost-effective strategy?

European journal of preventive cardiology·2011

Same author

Implementing the national invasive cervical cancer audit: a local perspective.

BJOG : an international journal of obstetrics and gynaecology·2010

Same author

Comparison between transcutaneous bilirubinometry and total serum bilirubin measurements in preterm infants <35 weeks gestation.

Annals of clinical biochemistry·2009

Same author

Targeting treatment using calculated cardiovascular disease risk: effective? A shot in the dark? Or is it time to change the paradigm?

International journal of clinical practice·2009

Accurate Down's syndrome screening relies on precise median calculations. This study introduces a new method for deriving medians, improving accuracy and ensuring reliable screening results for expectant mothers.

Area of Science:

Biochemistry
Medical Diagnostics
Genetics

Background:

Maternal serum analyte concentrations change with gestational age during Down's syndrome screening.
Multiples of the median (MoM) are used to normalize analyte concentrations, but assay drifts can lead to inaccurate median equations.
The NHS Fetal Anomaly Screening Programme and Down's Syndrome Screening Quality Assurance Service (DQASS) monitor screening accuracy.

Purpose of the Study:

To evaluate different median assignment techniques for Down's syndrome screening.
To improve the accuracy of median equations used in Down's syndrome screening.
To ensure the reliability of multiples of the median (MoM) calculations.

Main Methods:

Analysis of 61,368 Down's screening samples collected between October 2004 and December 2007.

More Related Videos

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Published on: January 27, 2018

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Published on: June 20, 2020

Related Experiment Videos

Last Updated: Jul 2, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Published on: January 27, 2018

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Published on: June 20, 2020

Evaluation of various median assignment techniques.

Development of a new paradigm for median equation derivation.

Main Results:

A novel approach to deriving median equations was developed.
The new method significantly enhances the probability of correct median values over time.
This improves the accuracy of Down's syndrome screening by ensuring reliable MoM distributions.

Conclusions:

The proposed change in median equation derivation improves screening accuracy.
Software developers should adopt the new median derivation methods.
Accurate median calculations are crucial for reliable Down's syndrome screening programs.