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Predicting worsening asthma control following the common cold
M J Walter1, M Castro, S J Kunselman
1Division of Pulmonary and Critical Care Medicine, Campus Box 8052, 660 South Euclid Ave., St Louis, MO 63110, USA. mwalter@im.wustl.edu
The European Respiratory Journal
|September 5, 2008
Summary
Asthma control can worsen after a common cold. Early cold severity, measured by the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21), predicts worsening asthma control in adults.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Epidemiology
Background:
- Asthma exacerbations are frequently triggered by viral infections like the common cold.
- Predicting asthma control deterioration after a cold is crucial for timely intervention.
Purpose of the Study:
- To identify early predictors of worsening asthma control following a common cold in adult asthmatic patients.
- To assess the relationship between cold severity and changes in asthma control.
Main Methods:
- Prospective multicenter cohort study involving 413 adult asthma patients.
- Utilized the mini-Asthma Control Questionnaire (mini-ACQ) for asthma control assessment.
- Employed the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) to quantify cold severity.
Main Results:
- Clinically significant worsening of asthma control was observed post-cold (mean mini-ACQ increase of 0.69).
- Early cold severity (WURSS-21 scores on days 1 and 2) significantly predicted subsequent changes in asthma control.
- Season, center, and cold duration were associated with asthma control changes in univariate analysis.
Conclusions:
- Cold severity in the initial 2 days of illness can predict subsequent asthma control changes in asthmatic individuals.
- This predictive capability may aid clinicians in preventing asthma control decline after a cold.
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