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Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q

Ivana Marinovic-Terzic1, Atsuko Yoshioka-Yamashita, Hideki Shimodaira

  • 1Moores Cancer Center, University of California, San Diego, School of Medicine, 3855 Health Sciences Drive, La Jolla, CA 92093, USA.

Proceedings of the National Academy of Sciences of the United States of America
|September 5, 2008
PubMed
Summary

The postmeiotic segregation 2 (PMS2) protein is crucial for cisplatin chemotherapy effectiveness. A common PMS2 variant (R20Q) impairs this DNA repair pathway, potentially affecting cancer treatment outcomes.

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