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RAGE ligation affects T cell activation and controls T cell differentiation.

Yali Chen1, Eitan M Akirav, Wei Chen

  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|September 5, 2008
PubMed
Summary

The pattern recognition receptor, RAGE, plays a key role in T cell differentiation. Inhibiting RAGE or deleting it reduces T cell responses in autoimmunity and allograft rejection, impacting Th1 cell development.

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