Related Experiment Video
Updated: Jul 2, 2026

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
Published on: May 26, 2023
Caveolin and proteasome in tocotrienol mediated myocardial protection
Manika Das1, Samarjit Das, Ping Wang
1Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.
Abstract:
The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins.
Related Concept Videos
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease IV: Preventive Measures
Mitochondrial Precursor Proteins
Most of the mitochondrial precursors...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Protein Transport into the Inner Mitochondrial Membrane
Transport of mitochondrial precursors across the TIM23 channel is driven by...
Peroxisomes