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Updated: Jul 2, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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p57 kip2's role beyond Schwann cell cycle control.

André Heinen1, David Kremer, Hans-Peter Hartung

  • 1Department of Neurology, Heinrich-Heine-University of Düsseldorf, Germany.

Cell Cycle (Georgetown, Tex.)
|September 5, 2008
PubMed
Summary

The p57(kip2) gene is a key regulator of Schwann cell differentiation, not proliferation. Suppressing p57(kip2) triggers cell cycle exit and differentiation, revealing its intrinsic role in peripheral nervous system development.

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