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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Late-phase reaction in ocular allergy.

Soo Hyun Choi¹, Leonard Bielory

¹UMDNJ, New Jersey Medical School, Newark, New Jersey, USA.

Current Opinion in Allergy and Clinical Immunology

|September 5, 2008

Summary

Ocular late-phase reaction, common in allergic rhinitis, is present in 50-100% of ocular allergy patients. This finding impacts disease severity and progression to systemic atopic disorders.

Area of Science:

Ophthalmology
Allergology
Immunology

Background:

Late-phase reaction is a known phenomenon in allergic rhinitis and asthma.
Its presence and implications in ocular allergy have not been fully elucidated.

Purpose of the Study:

To investigate the existence and characteristics of late-phase reactions in ocular allergy.
To determine the clinical significance of ocular late-phase reactions.

Main Methods:

A literature search was conducted using PubMed.
18 relevant articles from allergy and ophthalmology literature were identified and reviewed.

Main Results:

Ocular late-phase reaction is observed in 50-100% of allergic rhinoconjunctivitis patients.

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It is associated with disease progression to systemic atopic disorders.

Ocular late-phase reactions manifest in biphasic, multiphasic, and prolonged forms.

Conclusions:

Ocular late-phase reaction exists and plays a role in disease development, severity, and reactivity.
It signifies a continuum of mast-cell activation in the eye.
Understanding ocular late-phase reactions is crucial for developing targeted treatments for atopic eye disease.