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Related Experiment Video

Updated: Jul 2, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

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Published on: May 6, 2014

The role of complement in atherosclerosis.

Dorian O Haskard¹, Joseph J Boyle, Justin C Mason

¹Bywaters Centre for Vascular Inflammation, National Heart and Lung Institute, Imperial College, Hammersmith Hospital, London, UK. d.haskard@imperial.ac.uk

Current Opinion in Lipidology

|September 5, 2008

Summary

Recent research highlights the complement system's role in atherosclerosis, showing its involvement in lesion development and potential therapeutic targets. This review covers new findings on complement proteins and their impact on cardiovascular disease.

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Area of Science:

Cardiovascular Research
Immunology
Molecular Biology

Background:

Atherosclerosis pathogenesis involves complement activation, but its precise functional roles remain under investigation.
Recent studies continue to elucidate the complex interactions between the complement system and the development of atherosclerotic lesions.

Purpose of the Study:

To review recent publications on the complement system's involvement in atherosclerosis.
To highlight emerging findings regarding complement pathways and their implications for cardiovascular disease.

Main Methods:

Review of recent scientific literature focusing on complement system components and atherosclerosis.
Analysis of studies investigating complement protein associations with lipoproteins and cellular responses.

Main Results:

Complement proteins and regulators are linked to high-density lipoproteins.
Complement activation by modified LDL and downstream signaling pathways (C3a, C5a) are implicated.
Membrane attack complex (C5b-9) formation and its regulation (CD59) are key.
C1q shows a protective role in early lesion formation.
Therapeutic agents (Crry-Ig, soluble C1 inhibitor) demonstrate efficacy in vascular injury models.
Factor H polymorphism (Y402H) may increase atherosclerosis risk in specific populations.

Conclusions:

The complement system is highly relevant to the field of atherosclerosis.
Emerging research identifies novel therapeutic strategies targeting complement pathways for cardiovascular disease.